The Associations Between Circadian Genetic Factors And Cancer Survival

The circadian rhythm controls a range of important biological behaviors with a 24-hour cycle. The mammalian biological clock is a layered network of vibrators with a master clock locating in the neurons of suprachiasmatic nucleus (SCN) in the hypothalamus and a set of core and related circadian genes. Several lines of evidence from previous studies suggested the relationships between tumorigenesis and circadian rhythm disruption. However, the effects of circadian genetic factors in cancer survival remains uncertain. Therefore, it is important to review and explore the circadian genetic factors which might be linked to cancer survival. This paper aimed to evaluate the potential associations between circadian genetic factors and cancer survival by summarizing 30 epidemiological studies and searching 2 databases. The circadian genetic factors identified included both gene expression and SNPs. Our results showed that 16 circadian genes, PER1, PER2, PER3, CRY1, CRY2, BMAL1, CLOCK, NPAS2, NPAS3, TIMELESS, RORA, RORC, NR1D2, CK1ε, DEC1 and TIPIN, were significantly related to cancer survival across several types of cancer. The associations between circadian genes and cancer survival differed among different genes and cancer types

Towards universal health coverage: lessons from 10 years of healthcare reform in China.

Universal health coverage (UHC) is driving the global health agenda. Many countries have embarked on national policy reforms towards this goal, including China. In 2009, the Chinese government launched a new round of healthcare reform towards UHC, aiming to provide universal coverage of basic healthcare by the end of 2020. The year of 2019 marks the 10th anniversary of China's most recent healthcare reform. Sharing China's experience is especially timely for other countries pursuing reforms to achieve UHC. This study describes the social, economic and health context in China, and then reviews the overall progress of healthcare reform (1949 to present), with a focus on the most recent (2009) round of healthcare reform. The study comprehensively analyses key reform initiatives and major achievements according to four aspects: health insurance system, drug supply and security system, medical service system and public health service system. Lessons learnt from China may have important implications for other nations, including continued political support, increased health financing and a strong primary healthcare system as basis

Object Detection Difficulty: Suppressing Over-aggregation for Faster and Better Video Object Detection

Current video object detection (VOD) models often encounter issues with over-aggregation due to redundant aggregation strategies, which perform feature aggregation on every frame. This results in suboptimal performance and increased computational complexity. In this work, we propose an image-level Object Detection Difficulty (ODD) metric to quantify the difficulty of detecting objects in a given image. The derived ODD scores can be used in the VOD process to mitigate over-aggregation. Specifically, we train an ODD predictor as an auxiliary head of a still-image object detector to compute the ODD score for each image based on the discrepancies between detection results and ground-truth bounding boxes. The ODD score enhances the VOD system in two ways: 1) it enables the VOD system to select superior global reference frames, thereby improving overall accuracy; and 2) it serves as an indicator in the newly designed ODD Scheduler to eliminate the aggregation of frames that are easy to detect, thus accelerating the VOD process. Comprehensive experiments demonstrate that, when utilized for selecting global reference frames, ODD-VOD consistently enhances the accuracy of Global-frame-based VOD models. When employed for acceleration, ODD-VOD consistently improves the frames per second (FPS) by an average of 73.3% across 8 different VOD models without sacrificing accuracy. When combined, ODD-VOD attains state-of-the-art performance when competing with many VOD methods in both accuracy and speed. Our work represents a significant advancement towards making VOD more practical for real-world applications.Comment: 11 pages, 6 figures, accepted by ACM MM202

Impacts of Land Use Change on the Regional Climate: A Structural Equation Modeling Study in Southern China

With the frequent human activities operating on the earth, the impacts of land use change on the regional climate are increasingly perceptible. Under the background of the rapid urbanization, understanding the impacts of land use change on the regional climate change is vital and significant. In this study, we investigated the relationships between land use change and regional climate change through a structural equation model. Southern China was selected as the study area for its rapid urbanization and different structure of land use among its counties. The results indicate that the path coefficients of “vegetation,” “Urban and surrounding area,” and “other” to “climate” are −0.42, 0.20, and 0.46, respectively. Adding vegetation area is the main method to mitigate regional climate change. Urban and surrounding area and other areas influence regional climate by increasing temperature and precipitation to a certain extent. Adding grassland and forestry, restraining sprawl of built-up area, and making the most use of unused land are efficient ways to mitigate the regional climate change in Southern China. The results can provide feasible recommendations to land use policy maker

Two new genera of Apsilocephalidae from mid-Cretaceous Burmese amber

Apsilocephalidae is an enigmatic dipteran family erected by Nagatomi et al. (1991), including three extant genera and three additional extinct genera from the Eocene Baltic amber, Eocene Florissant, and mid-Cretaceous Burmese amber. We describe herein two new taxa, Myanmarpsilocephala grimaldii gen. et sp. nov. and Irwinimyia spinosa gen. et sp. nov., from mid-Cretaceous Burmese amber. The female genitalia of Myanmarpsilocephala gen. nov. and male genitalia of Irwinimyia gen. nov. are described and illustrated. The distribution of all Apsilocephalidae species and a key to all genera of Apsilocephalidae is provided. The described diversity of Apsilocephalidae in Burmese amber strongly suggests that apsilocephalid flies diversified at least by the mid-Cretaceous.This research was supported by the National Natural Science Foundation of China (41572010, 41622201, 41688103), the Chinese Academy of Sciences (XDPB05), and Youth Innovation Promotion Association of CAS (No. 2011224)